TEAD4

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

TEAD4 Gene(Protein Coding) TEA Domain Transcription Factor 4

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Biological Process cell fate specificationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process positive regulation of stem cell population maintenanceIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system developmentTAS:ProtInc1 Publication
Biological Process trophectodermal cell fate commitmentIEA:Ensembl

Nucleus