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Mouse Anti-TEAD4 Recombinant Antibody (CBYJT-2484) (CBMAB-T1633-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2484
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
TEAD4 (NP_003204, 151 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: ARGPGRPAVS GFWQGALPGQ AGTSHDVKPF SQQTYAVQPP LPLPGFESPA GPAPSPSAPP APPWQGRSVA SSKLWMLEFS AFLEQQQDPD TYNKHLFVHI GQSSPSYSDP
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 151-260

Target

Full Name
TEAD4 Gene(Protein Coding) TEA Domain Transcription Factor 4
Introduction
TEAD4 is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression.
Entrez Gene ID
7004
UniProt ID
Q15561
Alternative Names
TEA Domain Transcription Factor 4; TEA Domain Family Member 4; Transcription Factor 13-Like 1; Transcription Factor RTEF-1; TCF13L1; RTEF1; TEF3; Transcriptional Enhancer Factor 1-Related; Related Transcription Enhancer Factor 1B
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Biological Process
Biological Process cell fate specificationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Biological Process positive regulation of stem cell population maintenanceIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Biological Process skeletal system developmentTAS:ProtInc1 Publication
Biological Process trophectodermal cell fate commitmentIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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