TAOK3

TAOK3 is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. TAOK3 is a member of the GCK subfamily of STE20-like kinases.

TAO kinase 3

Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication

Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.

Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.