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Mouse Anti-TAOK3 Recombinant Antibody (4A2) (CBMAB-A8869-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4A2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TAOK3 (NP_057365.2, 809 a.a. ~ 898 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TAO kinase 3
Entrez Gene ID
51347
UniProt ID
Q9H2K8
Alternative Names
DKFZp666H245; DPK; FLJ31808; JIK; MAP3K18
Function
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Biological Process
Biological Process cellular response to DNA damage stimulusIDA:UniProtKB1 Publication
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process intracellular signal transductionIBA:GO_Central1 Publication
Biological Process MAPK cascadeIMP:HGNC-UCL1 Publication
Biological Process mitotic G2 DNA damage checkpoint signalingIMP:UniProtKB1 Publication
Biological Process negative regulation of JNK cascadeIDA:HGNC-UCL1 Publication
Biological Process neuron projection morphogenesisIBA:GO_Central1 Publication
Biological Process positive regulation of JNK cascadeIMP:HGNC-UCL1 Publication
Biological Process positive regulation of JUN kinase activityIMP:UniProtKB1 Publication
Biological Process positive regulation of stress-activated MAPK cascadeIMP:UniProtKB1 Publication
Biological Process protein autophosphorylationIDA:HGNC-UCL1 Publication
Biological Process protein phosphorylationIDA:HGNC-UCL1 Publication
Biological Process regulation of MAPK cascadeIBA:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell membrane
Also localized to the peripheral cell membrane.
PTM
Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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