STOM

This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants.

Stomatin

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

Biological Process positive regulation by host of viral genome replicationIEA:Ensembl
Biological Process positive regulation of protein targeting to membraneIEA:Ensembl
Biological Process positive regulation of viral processIEA:Ensembl
Biological Process regulation of acid-sensing ion channel activityIEA:Ensembl

Cell membrane
Cytoplasm, cytoskeleton
Cell membrane
Membrane raft
Melanosome
Cytoplasmic vesicle
Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190).
Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190).
Associates with alpha-granular lipid rafts (PubMed:12130500).
Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).