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Mouse Anti-STOM Monoclonal Antibody (AT33F5) (CBMAB-1568-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
AT33F5
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant fragment corresponding to Human STOM aa 55-288. Sequence: KIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIP PQEILTKDSV TISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLR NVLGTKNLSQILSDREEIAHNM QSTLDDATDAWGIKVERVEIKDVKLP VQLQRAMAAEAEASREARAKVIAAEGEMNASRAL KEASMVITESPAAL QLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Stomatin
Introduction
STOM is a member of a highly conserved family of integral membrane proteins which localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the STOM is associated with hereditary stomatocytosis, a form of hemolytic anemia.
Entrez Gene ID
2040
UniProt ID
P27105
Alternative Names
BND7; EPB7; EPB72
Function
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
Biological Process
Biological Process positive regulation by host of viral genome replicationIEA:Ensembl
Biological Process positive regulation of protein targeting to membraneIEA:Ensembl
Biological Process positive regulation of viral processIEA:Ensembl
Biological Process regulation of acid-sensing ion channel activityIEA:Ensembl
Cellular Location
Cell membrane
Cytoplasm, cytoskeleton
Cell membrane
Membrane raft
Melanosome
Cytoplasmic vesicle
Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190).
Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190).
Associates with alpha-granular lipid rafts (PubMed:12130500).
Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).
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For research use only. Not intended for any clinical use.

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