STC2

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq]

stanniocalcin 2

Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process decidualizationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process endoplasmic reticulum unfolded protein responseIEA:Ensembl
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process regulation of hormone biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of store-operated calcium entryIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process response to peptide hormoneIEA:Ensembl
Biological Process response to vitamin DIEA:Ensembl

Secreted