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Rat Anti-STC2 (AA 25-302) Recombinant Antibody (CBXS-0769) (CBMAB-S3697-CQ)


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Summary

Host Animal
Rat
Specificity
Human
Clone
CBXS-0769
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 25-302

Target

Full Name
stanniocalcin 2
Introduction
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
Entrez Gene ID
8614
UniProt ID
O76061
Alternative Names
STC-2; STCRP
Function
Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
Biological Process
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to hypoxiaIEA:Ensembl
Biological Process decidualizationIEA:Ensembl
Biological Process embryo implantationIEA:Ensembl
Biological Process endoplasmic reticulum unfolded protein responseIEA:Ensembl
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process regulation of hormone biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of store-operated calcium entryIEA:Ensembl
Biological Process response to oxidative stressIEA:Ensembl
Biological Process response to peptide hormoneIEA:Ensembl
Biological Process response to vitamin DIEA:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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