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STAT6

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [provided by RefSeq]

Full Name

STAT6

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Biological Process

Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to reactive nitrogen speciesIEA:Ensembl
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentIBA:GO_Central
Gene expressionIEA:Ensembl
Growth hormone receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Interleukin-4-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland epithelial cell proliferationIEA:Ensembl
Mammary gland morphogenesisIEA:Ensemblegative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of isotype switching to IgE isotypesIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
T-helper 1 cell lineage commitmentIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.

PTM

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300).
Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity).
Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.

Anti-STAT6 antibodies

Mouse Anti-STAT6 Monoclonal Antibody (1C6) (CBMAB-0208-LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C6

Application*: IP, E, WB

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-6148) (CBMAB-S6311-CQ)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-6148

Application*: WB, IP, IC, F

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3452) (CBMAB-S6183-CQ)

SDS

Target: STAT6

Host: Mouse

Specificity: Human

Clone: CBXS-3452

Application*: WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3396) (CBMAB-S6130-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-3396

Application*: F

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2122) (CBMAB-S4886-CQ)

SDS

Target: STAT6

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-2122

Application*: WB, IP, IF, P, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2119) (CBMAB-S4884-CQ)

SDS

Target: STAT6

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-2119

Application*: WB, IP, IF, P

Rat Anti-STAT6 Recombinant Antibody (CBXS-1988) (CBMAB-S4757-CQ)

SDS

Target: STAT6

Host: Rat

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1988

Application*: IC

Rat Anti-STAT6 Recombinant Antibody (CBXS-1987) (CBMAB-S4756-CQ)

SDS

Target: STAT6

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1987

Application*: WB

Rat Anti-STAT6 Recombinant Antibody (CBXS-1890) (CBMAB-S4684-CQ)

SDS

Target: STAT6

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-1890

Application*: WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-1734) (CBMAB-S0105-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1734

Application*: IS

Rabbit Anti-STAT6 Recombinant Antibody (YE361) (CBMAB-S0197-CQ)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: YE361

Application*: F, IF

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3765) (CBMAB-S0221-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-3765

Application*: WB, IP

Mouse Anti-STAT6 Recombinant Antibody (CBXS-4629) (CBMAB-S0243-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-4629

Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5668) (CBMAB-S0262-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-5668

Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5728) (CBMAB-S0269-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-5728

Application*: WB, E

Human Anti-STAT6 Recombinant Antibody (CBXS-3556) (CBMAB-S0398-CQ)

SDS

Target: STAT6

Host: Human

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBXS-3556

Application*: F

Mouse Anti-STAT6 Recombinant Antibody (CBXS-1117) (CBMAB-S0405-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1117

Application*: F, IF, IF

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5801) (CBMAB-S0658-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-5801

Application*: WB, P, IF

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-4271) (CBMAB-S1520-CQ)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXS-4271

Application*: CI, F, IC, IF, P, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5259) (CBMAB-S2474-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBXS-5259

Application*: IC, IF, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-5276) (CBMAB-S2490-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Dog, Human

Clone: CBXS-5276

Application*: C, E, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-0761) (CBMAB-S3689-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-0761

Application*: IH

Mouse Anti-STAT6 Recombinant Antibody (CBXS-1101) (CBMAB-S3987-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1101

Application*: E

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-1451) (CBMAB-S4309-CQ)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1451

Application*: WB, F, IF

Rabbit Anti-STAT6 Recombinant Antibody (CBXS-1669) (CBMAB-S4513-CQ)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1669

Application*: WB, IC

Mouse Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (A15137E) (PTM-CBMAB-0105LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: A15137E

Application*: IS

Mouse Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (16E12) (PTM-CBMAB-0302LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 16E12

Application*: C, E, WB

Mouse Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (6D782) (PTM-CBMAB-0458LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D782

Application*: E, WB

Rabbit Anti-STAT6 (Phosphorylated Y641) Recombinant Antibody (C11A12) (PTM-CBMAB-0538LY)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: C11A12

Application*: WB

Mouse Anti-Stat6 Recombinant Antibody (2B2-B6-D7) (CBMAB-Z0470-LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey

Clone: 2B2-B6-D7

Application*: WB, IC

Mouse Anti-STAT6 Recombinant Antibody (4G7) (CBMAB-A8653-LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4G7

Application*: WB, E

Mouse Anti-STAT6 Recombinant Antibody (6C10) (CBMAB-A8654-LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6C10

Application*: WB, E

Rabbit Anti-STAT6 Recombinant Antibody (D3H4) (CBMAB-CP2620-LY)

SDS

Target: STAT6

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey, Cattle, Dog, Pig

Clone: D3H4

Application*: WB, IP, CI

Mouse Anti-STAT6 Recombinant Antibody (7D3) (CBMAB-AO993LY)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Monkey

Clone: 7D3

Application*: WB, IF

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3365) (CBMAB-S6102-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-3365

Application*: E, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-3251) (CBMAB-S5992-CQ)

SDS

Target: STAT6

Host: Mouse

Specificity: Human

Clone: CBXS-3251

Application*: E, IF, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2473) (CBMAB-S5230-CQ)

SDS

Target: STAT6

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse, Rat

Clone: CBXS-2473

Application*: E, WB

Mouse Anti-STAT6 Recombinant Antibody (CBXS-2164) (CBMAB-S4927-CQ)

SDS

Target: STAT6

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBXS-2164

Application*: WB, IP, IF, E

STAT6 Matched Antibody Pair (1151) (APMAB-1151LY)

SDS

Target: STAT6

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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