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Rabbit Anti-STAT6 Recombinant Antibody (CBXS-1669) (CBMAB-S4513-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1669
Antibody Isotype
IgG
Application
WB, ICC

Basic Information

Immunogen
Phosphopeptide containing human STAT6 Y641 site. Accession # P42226
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STAT6
Introduction
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6778
UniProt ID
P42226
Alternative Names
STAT6B; STAT6C; D12S1644; IL-4-STAT
Function
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Biological Process
Cellular response to hydrogen peroxideIEA:Ensembl
Cellular response to reactive nitrogen speciesIEA:Ensembl
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense responseManual Assertion Based On ExperimentIBA:GO_Central
Gene expressionIEA:Ensembl
Growth hormone receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Interleukin-4-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland epithelial cell proliferationIEA:Ensembl
Mammary gland morphogenesisIEA:Ensemblegative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of isotype switching to IgE isotypesIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
T-helper 1 cell lineage commitmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Translocated into the nucleus in response to phosphorylation.
PTM
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300).
Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity).
Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.
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For research use only. Not intended for any clinical use.

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