SSTR5

Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.

Somatostatin Receptor 5

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

Biological Process cellular response to glucocorticoid stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of insulin secretionManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane

Extracellular: 1-38
Helical: 39-66
Cytoplasmic: 67-76
Helical: 77-101
Extracellular: 102-113
Helical: 114-135
Cytoplasmic: 136-157
Helical: 158-178
Extracellular: 179-197
Helical: 198-222
Cytoplasmic: 223-247
Helical: 248-273
Extracellular: 274-283
Helical: 284-308
Cytoplasmic: 309-364

Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.