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Mouse Anti-SSTR5 Recombinant Antibody (CBXS-0740) (CBMAB-S3670-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0740
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Somatostatin Receptor 5
Introduction
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.
Entrez Gene ID
6755
UniProt ID
P35346
Alternative Names
Somatostatin Receptor 5; SS-5-R; Somatostatin Receptor Subtype 5; Somatostatin Receptor Type 5; SS5-R; SS5R;
Function
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Biological Process
Biological Process cellular response to glucocorticoid stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of insulin secretionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-38
Helical: 39-66
Cytoplasmic: 67-76
Helical: 77-101
Extracellular: 102-113
Helical: 114-135
Cytoplasmic: 136-157
Helical: 158-178
Extracellular: 179-197
Helical: 198-222
Cytoplasmic: 223-247
Helical: 248-273
Extracellular: 274-283
Helical: 284-308
Cytoplasmic: 309-364
PTM
Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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