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SRD5A1

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).
Full Name
Steroid 5 Alpha-Reductase 1
Function
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Biological Process
Biological Process androgen biosynthetic processTAS:Reactome
Biological Process androgen catabolic processIEA:Ensembl
Biological Process bone developmentIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process cellular response to epinephrine stimulusIEA:Ensembl
Biological Process cellular response to estradiol stimulusIEA:Ensembl
Biological Process cellular response to growth factor stimulusIEA:Ensembl
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process cellular response to starvationIEA:Ensembl
Biological Process cellular response to testosterone stimulusIEA:Ensembl
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process circadian sleep/wake cycle, REM sleepIEA:Ensembl
Biological Process diterpenoid metabolic processIEA:Ensembl
Biological Process female genitalia developmentIEA:Ensembl
Biological Process hippocampus developmentIEA:Ensembl
Biological Process hypothalamus developmentIEA:Ensembl
Biological Process liver developmentIEA:Ensembl
Biological Process male genitalia developmentIEA:Ensembl
Biological Process male gonad developmentIEA:Ensembl
Biological Process pituitary gland developmentIEA:Ensembl
Biological Process progesterone metabolic processIEA:Ensembl
Biological Process response to estrogenIEA:Ensembl
Biological Process response to follicle-stimulating hormoneIEA:Ensembl
Biological Process response to fungicideIEA:Ensembl
Biological Process response to growth hormoneIEA:Ensembl
Biological Process response to muscle activityIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin metabolic processIEA:Ensembl
Biological Process sex determination1 PublicationNAS:ProtInc
Biological Process spinal cord developmentIEA:Ensembl
Biological Process steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thalamus developmentIEA:Ensembl
Biological Process urogenital system developmentIEA:Ensembl
Cellular Location
Microsome membrane
Endoplasmic reticulum membrane

Anti-SRD5A1 antibodies

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Target: SRD5A1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4002
Application*: E, WB, IH, IF
Target: SRD5A1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0704
Application*: SE, E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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