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Mouse Anti-SRD5A1 Recombinant Antibody (CBXS-0704) (CBMAB-S3637-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0704
Antibody Isotype
IgG1, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
SRD5A2 (NP_000339.2, 28 a.a.-65 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Steroid 5 Alpha-Reductase 1
Introduction
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).
Entrez Gene ID
6715
UniProt ID
P18405
Alternative Names
Steroid 5 Alpha-Reductase 1; Steroid-5-Alpha-Reductase, Alpha Polypeptide 1 (3-Oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 1); 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 1; Steroid 5-Alpha-Reductase 1; EC 1.3.1.22; SR Type 1; S5AR 1;
Function
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Biological Process
Biological Process androgen biosynthetic processTAS:Reactome
Biological Process androgen catabolic processIEA:Ensembl
Biological Process bone developmentIEA:Ensembl
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process cellular response to cAMPIEA:Ensembl
Biological Process cellular response to dexamethasone stimulusIEA:Ensembl
Biological Process cellular response to epinephrine stimulusIEA:Ensembl
Biological Process cellular response to estradiol stimulusIEA:Ensembl
Biological Process cellular response to growth factor stimulusIEA:Ensembl
Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process cellular response to starvationIEA:Ensembl
Biological Process cellular response to testosterone stimulusIEA:Ensembl
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process circadian sleep/wake cycle, REM sleepIEA:Ensembl
Biological Process diterpenoid metabolic processIEA:Ensembl
Biological Process female genitalia developmentIEA:Ensembl
Biological Process hippocampus developmentIEA:Ensembl
Biological Process hypothalamus developmentIEA:Ensembl
Biological Process liver developmentIEA:Ensembl
Biological Process male genitalia developmentIEA:Ensembl
Biological Process male gonad developmentIEA:Ensembl
Biological Process pituitary gland developmentIEA:Ensembl
Biological Process progesterone metabolic processIEA:Ensembl
Biological Process response to estrogenIEA:Ensembl
Biological Process response to follicle-stimulating hormoneIEA:Ensembl
Biological Process response to fungicideIEA:Ensembl
Biological Process response to growth hormoneIEA:Ensembl
Biological Process response to muscle activityIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin metabolic processIEA:Ensembl
Biological Process sex determination1 PublicationNAS:ProtInc
Biological Process spinal cord developmentIEA:Ensembl
Biological Process steroid biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thalamus developmentIEA:Ensembl
Biological Process urogenital system developmentIEA:Ensembl
Cellular Location
Microsome membrane
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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