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SLC6A3

SLC6A3 is a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Full Name
Solute Carrier Family 6 Member 3
Function
Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460).
Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity).
Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
Biological Process
Biological Process adenohypophysis developmentIEA:Ensembl
Biological Process agingIEA:Ensembl
Biological Process dopamine biosynthetic processIEA:Ensembl
Biological Process dopamine catabolic processIEA:Ensembl
Biological Process dopamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process dopamine uptake involved in synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process hyaloid vascular plexus regressionISS:UniProtKB
Biological Process lactationIEA:Ensembl
Biological Process locomotory behaviorIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process norepinephrine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of multicellular organism growthIEA:Ensembl
Biological Process prepulse inhibitionIEA:Ensembl
Biological Process regulation of dopamine metabolic processIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to cocaineIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to iron ionIEA:Ensembl
Biological Process response to nicotineIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sensory perception of smellIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell projection, neuron projection
Cell projection, axon
Localizes to neurite tips in neuronal cells (By similarity).
Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity).
Involvement in disease
Parkinsonism-dystonia 1, infantile-onset (PKDYS1):
An autosomal recessive neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.

Anti-SLC6A3 antibodies

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Target: SLC6A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: mAb16
Application*: E, IC, IF, IH, P, IP, WB
Target: SLC6A3
Host: Mouse
Specificity: Rat
Clone: CBXS-0492
Application*: WB, IC, P, C, E
Target: SLC6A3
Host: Mouse
Specificity: Human
Clone: CBXS-0491
Application*: WB, IC, P, C, E
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0490
Application*: IC, IH, WB
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0489
Application*: C, WB
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5072
Application*: C, WB
Target: SLC6A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-4685
Application*: IH
Target: SLC6A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBXS-6175
Application*: WB, E, IH, IF, IP, P
Target: SLC6A3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: Y12C
Application*: E, IC, C, P, WB
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: hDAT-NT
Application*: IC, C, P
Target: SLC6A3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: 6V-23-23
Application*: WB, P
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Monkey, Mouse
Clone: 2Q45
Application*: IC, IH, WB
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Monkey, Mouse, Rat
Clone: 10B2323
Application*: IH, WB
Target: SLC6A3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-509
Application*: E, IF, WB
Target: SLC6A3
Host: Rat
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: hDAT-LOOP
Application*: WB, C, IC, IF
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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