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Mouse Anti-SLC6A3 Recombinant Antibody (6V-23-23) (CBMAB-D2243-YC)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
6V-23-23
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 6 Member 3
Introduction
SLC6A3 is a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
Entrez Gene ID
Mouse13162
Rat24898
UniProt ID
MouseQ61327
RatP23977
Alternative Names
Solute Carrier Family 6 Member 3; Solute Carrier Family 6 (Neurotransmitter Transporter, Dopamine), Member 3; Solute Carrier Family 6 (Neurotransmitter Transporter), Member 3; Dopamine Transporter 1; DA Transporter; DAT1;
Function
Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460).
Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity).
Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
Biological Process
Biological Process adenohypophysis developmentIEA:Ensembl
Biological Process agingIEA:Ensembl
Biological Process dopamine biosynthetic processIEA:Ensembl
Biological Process dopamine catabolic processIEA:Ensembl
Biological Process dopamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process dopamine uptake involved in synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process hyaloid vascular plexus regressionISS:UniProtKB
Biological Process lactationIEA:Ensembl
Biological Process locomotory behaviorIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process norepinephrine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of multicellular organism growthIEA:Ensembl
Biological Process prepulse inhibitionIEA:Ensembl
Biological Process regulation of dopamine metabolic processIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to cocaineIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to iron ionIEA:Ensembl
Biological Process response to nicotineIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sensory perception of smellIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Cell projection, neuron projection
Cell projection, axon
Localizes to neurite tips in neuronal cells (By similarity).
Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity).
Involvement in disease
Parkinsonism-dystonia 1, infantile-onset (PKDYS1):
An autosomal recessive neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradykinesia and pyramidal tract signs.
More Infomation
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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