SLC6A20

Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq]

solute carrier family 6 (proline IMINO transporter), member 20

Mediates the Na+- and Cl--dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147, PubMed:19033659, PubMed:33428810).
Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810).

Biological Process amino acid import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process amino acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process amino-acid betaine transportISS:ARUK-UCL
Biological Process glycine import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycine transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process L-isoleucine import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process L-proline import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process proline import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process proline transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Apical cell membrane
Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.

Hyperglycinuria (HG):
A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.
Iminoglycinuria (IG):
A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine.