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Mouse Anti-SLC6A20 Recombinant Antibody (C-11) (CBMAB-X0068-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C-11
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 6 (proline IMINO transporter), member 20
Introduction
SLC6A20 is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. SLC6A20 is expressed in kidney. SLC6A20 mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. SLC6A20 is involved in the transport of glycine.
Entrez Gene ID
54716
UniProt ID
Q9NP91
Alternative Names
XT3; SIT1; Xtrp3
Function
Mediates the Na+- and Cl--dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147, PubMed:19033659, PubMed:33428810).
Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (PubMed:33428810).
Biological Process
Biological Process amino acid import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process amino acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process amino-acid betaine transportISS:ARUK-UCL
Biological Process glycine import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glycine transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process L-isoleucine import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process L-proline import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process proline import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process proline transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Apical cell membrane
Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.
Involvement in disease
Hyperglycinuria (HG):
A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.
Iminoglycinuria (IG):
A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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