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SLC2A5

The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption.

Full Name

Solute Carrier Family 2 Member 5

Function

Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649, PubMed:17710649, PubMed:29548810).
Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905).
Essential for fructose uptake in the small intestine (By similarity).
Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity).
Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).

Biological Process

Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to fructose stimulusISS:UniProtKB
Biological Process fructose import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intestinal hexose absorptionTAS:Reactome
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of systemic arterial blood pressure mediated by a chemical signalISS:UniProtKB
Biological Process response to fructoseISS:UniProtKB

Cellular Location

Apical cell membrane
Cell membrane
Cell membrane, sarcolemma
Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.

Anti-SLC2A5 antibodies

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-4440) (CBMAB-S1682-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4440

Application*: P, IP, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-4259) (CBMAB-S1510-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4259

Application*: F, IF, IH, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3725) (CBMAB-S1000-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXS-3725

Application*: IC, IF, IH, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3704) (CBMAB-S0979-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3704

Application*: IF, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3690) (CBMAB-S0965-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3690

Application*: F, IF, IP, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-3654) (CBMAB-S0933-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3654

Application*: P, IP, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-5981) (CBMAB-S0828-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5981

Application*: IP, WB

Mouse Anti-SLC2A5 Recombinant Antibody (CBXS-5974) (CBMAB-S0821-CQ)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5974

Application*: P, WB

Mouse Anti-SLC2A5 Recombinant Antibody (9H4) (CBMAB-G6588-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 9H4

Application*: WB

Mouse Anti-SLC2A5 Recombinant Antibody (9G8) (CBMAB-G6587-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9G8

Application*: IC/IF, IH, P, WB

Mouse Anti-SLC2A5 Recombinant Antibody (9F3) (CBMAB-G6586-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 9F3

Application*: WB

Mouse Anti-SLC2A5 Recombinant Antibody (2C4) (CBMAB-G6585-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C4

Application*: IH, P, IP, WB

Mouse Anti-SLC2A5 Recombinant Antibody (20E1) (CBMAB-G6584-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 20E1

Application*: F

Mouse Anti-SLC2A5 Recombinant Antibody (14C8) (CBMAB-G6583-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 14C8

Application*: F

Mouse Anti-SLC2A5 Recombinant Antibody (13A10) (CBMAB-G6582-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13A10

Application*: WB

Mouse Anti-SLC2A5 Recombinant Antibody (12F2) (CBMAB-G6581-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 12F2

Application*: WB

Mouse Anti-SLC2A5 Recombinant Antibody (11E1) (CBMAB-G6580-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11E1

Application*: IC/IF, WB

Mouse Anti-SLC2A5 Recombinant Antibody (11D11) (CBMAB-G6579-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11D11

Application*: IH, P, IP, WB

Mouse Anti-SLC2A5 Recombinant Antibody (11C105) (CBMAB-G6578-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 11C105

Application*: F

Mouse Anti-SLC2A5 Recombinant Antibody (195205) (CBMAB-G1187-LY)

SDS

Target: SLC2A5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 195205

Application*: F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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