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Mouse Anti-SLC2A5 Recombinant Antibody (11D11) (CBMAB-G6579-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
11D11
Antibody Isotype
IgG1
Application
IHC, IHC-P, IP, WB

Basic Information

Immunogen
Protein expressed in 293T cell transfected with human GLUT5 expression vector
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Solute Carrier Family 2 Member 5
Introduction
The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
Entrez Gene ID
6518
UniProt ID
P22732
Alternative Names
Solute Carrier Family 2 Member 5; Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter); Member 5; Glucose Transporter Type 5; Small Intestine; GLUT-5; GLUT5; Solute Carrier Family 2; Facilitated Glucose Transporter Member 5; Glucose Transporter-Like Protein 5; Testicular Tissue Protein Li 81; Fructose Transporter;
Function
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543, PubMed:16186102, PubMed:28083649, PubMed:17710649, PubMed:29548810).
Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905).
Essential for fructose uptake in the small intestine (By similarity).
Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity).
Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to fructose stimulusISS:UniProtKB
Biological Process fructose import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intestinal hexose absorptionTAS:Reactome
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of systemic arterial blood pressure mediated by a chemical signalISS:UniProtKB
Biological Process response to fructoseISS:UniProtKB
Cellular Location
Apical cell membrane
Cell membrane
Cell membrane, sarcolemma
Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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