SLC2A2

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.

solute carrier family 2 member 2

Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8457197).
Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028).
May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500).
Also able to mediate the transport of dehydroascorbate (PubMed:23396969).

Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dehydroascorbic acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process galactose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane

Fanconi-Bickel syndrome (FBS):
Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.

N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.