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Recombinant Rabbit Anti-SLC2A2 Antibody (CBAb221) (CBMAB-Ab221-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBAb221
Antibody Isotype
IgG
Application
WB 1:1000-1:2000

Basic Information

Immunogen
A synthetic peptide of human SLC2A2
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 2 member 2
Introduction
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.
Entrez Gene ID
6514
UniProt ID
P11168
Alternative Names
SLC2A2; GLUT2; solute carrier family 2 member 2
Function
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8457197).
Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028).
May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500).
Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
Biological Process
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dehydroascorbic acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fructose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process galactose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Fanconi-Bickel syndrome (FBS):
Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
PTM
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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