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SLC22A2

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq]
Full Name
solute carrier family 22 (organic cation transporter), member 2
Function
Mediates tubular uptake of organic compounds from circulation. Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186).
Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processISS:ARUK-UCL
Biological Process amine transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process body fluid secretionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process choline transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process export across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process histamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process L-alpha-amino acid transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process L-arginine import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process norepinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process organic cation transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process positive regulation of gene expressionISS:ARUK-UCL
Biological Process purine-containing compound transmembrane transportTAS:Reactome
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process toxin transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process xenobiotic transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Membrane

Anti-SLC22A2 antibodies

+ Filters
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Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2872
Application*: IHC
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1871
Application*: IH
Target: SLC22A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1277
Application*: WB, P
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0438
Application*: E, WB
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5318
Application*: IH
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5317
Application*: IH
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CL0631
Application*: IH, P
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CL0628
Application*: IH, P
Target: SLC22A2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A5
Application*: IH
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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