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Mouse Anti-SLC22A2 Recombinant Antibody (CBXS-1871) (CBMAB-S4668-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1871
Antibody Isotype
IgG2a
Application
IHC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human SLC-22A2, Accession # O15244
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 22 (organic cation transporter), member 2
Introduction
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.
Entrez Gene ID
6582
UniProt ID
O15244
Alternative Names
Solute Carrier Family 22 Member 2; Organic Cation Transporter 2; Solute Carrier Family 22 (Organic Cation Transporter), Member 2; OCT2; HOCT2;
Function
Mediates tubular uptake of organic compounds from circulation. Mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186).
Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processISS:ARUK-UCL
Biological Process amine transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process body fluid secretionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process choline transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process export across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process histamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process L-alpha-amino acid transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process L-arginine import across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process norepinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process organic cation transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process positive regulation of gene expressionISS:ARUK-UCL
Biological Process purine-containing compound transmembrane transportTAS:Reactome
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process toxin transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process xenobiotic transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Membrane
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For research use only. Not intended for any clinical use.

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