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SLC19A3

SLC19A3 is a member of the reduced folate family of micronutrient transporter genes.[supplied by OMIM
Full Name
solute carrier family 19, member 3
Function
Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
Biological Process
Biological Process thiamine transmembrane transportISS:BHF-UCL
Biological Process thiamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process thiamine-containing compound metabolic processTAS:Reactome
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Involvement in disease
Thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive type (THMD2):
An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-53
Helical: 54-74
Cytoplasmic: 75-81
Helical: 82-102
Extracellular: 103-110
Helical: 111-131
Cytoplasmic: 132-144
Helical: 145-165
Extracellular: 166-169
Helical: 170-190
Cytoplasmic: 191-282
Helical: 283-303
Extracellular: 304-316
Helical: 317-337
Cytoplasmic: 338-342
Helical: 343-363
Extracellular: 364-375
Helical: 376-396
Cytoplasmic: 397-405
Helical: 406-426
Extracellular: 427-434
Helical: 435-455
Cytoplasmic: 456-496

Anti-SLC19A3 antibodies

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Target: SLC19A3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B2
Application*: SE, E
Target: SLC19A3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3020
Application*: E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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