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Mouse Anti-SLC19A3 Recombinant Antibody (3B2) (CBMAB-A8176-LY)


See all SLC19A3 antibodies
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B2
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
SLC19A3 (NP_079519.1, 191 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 19, member 3
Introduction
SLC19A3 is a member of the reduced folate family of micronutrient transporter genes.[supplied by OMIM
Entrez Gene ID
80704
UniProt ID
Q9BZV2
Alternative Names
THTR2
Function
Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
Biological Process
Biological Process thiamine transmembrane transportISS:BHF-UCL
Biological Process thiamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process thiamine-containing compound metabolic processTAS:Reactome
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Involvement in disease
Thiamine metabolism dysfunction syndrome 2, biotin- or thiamine-responsive type (THMD2):
An autosomal recessive metabolic disorder characterized by episodic encephalopathy, often triggered by febrile illness, presenting as confusion, seizures, external ophthalmoplegia, dysphagia, and sometimes coma and death. If untreated, encephalopathies can result in permanent dystonia. Brain imaging may show characteristic bilateral lesions of the basal ganglia.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-53
Helical: 54-74
Cytoplasmic: 75-81
Helical: 82-102
Extracellular: 103-110
Helical: 111-131
Cytoplasmic: 132-144
Helical: 145-165
Extracellular: 166-169
Helical: 170-190
Cytoplasmic: 191-282
Helical: 283-303
Extracellular: 304-316
Helical: 317-337
Cytoplasmic: 338-342
Helical: 343-363
Extracellular: 364-375
Helical: 376-396
Cytoplasmic: 397-405
Helical: 406-426
Extracellular: 427-434
Helical: 435-455
Cytoplasmic: 456-496
More Infomation
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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