SKIL

The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

SKI-like oncogene

May have regulatory role in cell division or differentiation in response to extracellular signals.

Biological Process blastocyst formationIEA:Ensembl
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process lens fiber cell differentiationIEA:Ensembl
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of axonogenesisIMP:UniProtKB
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process regulation of cell cycleIEA:Ensembl
Biological Process response to antibioticIEP:UniProtKB
Biological Process response to cytokineIEA:Ensembl
Biological Process response to growth factorIDA:UniProtKB
Biological Process skeletal muscle tissue developmentIDA:UniProtKB
Biological Process spermatogenesisIEA:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl

acrosomal vesicle
cytoplasm
nucleoplasm
nucleus
PML body
protein-containing complex
transcription regulator complex

Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.