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Mouse Anti-SKIL Recombinant Antibody (CBXS-4599) (CBMAB-S1839-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4599
Antibody Isotype
IgG1
Application
WB, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SKI-like oncogene
Introduction
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Entrez Gene ID
6498
UniProt ID
P12757
Alternative Names
SKI Like Proto-Oncogene; SKI-Like Oncogene; Sno; Ski-Related Oncogene SnoN; Ski-Related Oncogene; Ski-Related Protein;
Function
May have regulatory role in cell division or differentiation in response to extracellular signals.
Biological Process
Biological Process blastocyst formationIEA:Ensembl
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process lens fiber cell differentiationIEA:Ensembl
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of axonogenesisIMP:UniProtKB
Biological Process positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA:Ensembl
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageIEA:Ensembl
Biological Process regulation of cell cycleIEA:Ensembl
Biological Process response to antibioticIEP:UniProtKB
Biological Process response to cytokineIEA:Ensembl
Biological Process response to growth factorIDA:UniProtKB
Biological Process skeletal muscle tissue developmentIDA:UniProtKB
Biological Process spermatogenesisIEA:Ensembl
Biological Process transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Cellular Location
acrosomal vesicle
cytoplasm
nucleoplasm
nucleus
PML body
protein-containing complex
transcription regulator complex
PTM
Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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