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SIX5

The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2.

Full Name

SIX5

Function

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity).
Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).

Biological Process

Biological Process lens development in camera-type eyeIEA:Ensembl
Biological Process Leydig cell proliferationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process negative regulation of skeletal muscle satellite cell proliferationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatid developmentIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus

Involvement in disease

Branchiootorenal syndrome 2 (BOR2):
A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations.

Anti-SIX5 antibodies

Mouse Anti-SIX5 Antibody (3A1) (CBMAB-1581CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: 3A1

Application*: WB, IF

Mouse Anti-SIX5 Antibody (6C1) (CBMAB-1580CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6C1

Application*: WB, IF

Mouse Anti-SIX5 Antibody (9G10) (CBMAB-1579CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9G10

Application*: WB, IF

Mouse Anti-SIX5 Antibody (10D2) (CBMAB-1578CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10D2

Application*: WB, IF

Mouse Anti-SIX5 Antibody (10B3) (CBMAB-1577CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B3

Application*: WB, IF

Mouse Anti-SIX5 Antibody (6E10) (CBMAB-1576CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6E10

Application*: WB, IF

Mouse Anti-SIX5 Antibody (7G4) (CBMAB-1575CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7G4

Application*: WB, IF

Mouse Anti-SIX5 Antibody (3G10) (CBMAB-1574CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3G10

Application*: WB, IF

Mouse Anti-SIX5 Antibody (1C11) (CBMAB-1573CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C11

Application*: WB, IF

Mouse Anti-SIX5 Antibody (10B12) (CBMAB-1572CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B12

Application*: WB, IF

Mouse Anti-SIX5 Antibody (3E11) (CBMAB-1571CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3E11

Application*: WB, IF

Mouse Anti-SIX5 Antibody (3D9) (CBMAB-1570CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3D9

Application*: WB, IF

Mouse Anti-SIX5 Antibody (3B4) (CBMAB-1569CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B4

Application*: WB, IF

Mouse Anti-SIX5 Antibody (4E7) (CBMAB-1568CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E7

Application*: WB, IF

Mouse Anti-SIX5 Antibody (2H1) (CBMAB-1567CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2H1

Application*: WB, IF

Mouse Anti-SIX5 Antibody (4H7) (CBMAB-1566CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4H7

Application*: WB, IF

Mouse Anti-SIX5 Antibody (2A6) (CBMAB-1565CQ)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A6

Application*: WB, IF

Mouse Anti-SIX5 Monoclonal Antibody (2H4) (CBMAB-0109-LY)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2H4

Application*: IP, M

Mouse Anti-SIX5 Monoclonal Antibody (2B11) (CBMAB-0108-LY)

SDS

Target: SIX5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2B11

Application*: IP, M

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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