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Mouse Anti-SIX5 Antibody (1C11) (CBMAB-1573CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1C11
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SIX5
Introduction
The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Diseases associated with SIX5 include Branchiootorenal Syndrome 2 and Six5-Related Branchiootorenal Spectrum Disorders. GO annotations related to this gene include sequence-specific DNA binding.
Entrez Gene ID
147912
UniProt ID
Q8N196
Alternative Names
BOR2; DMAHP
Function
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity).
Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity).
Biological Process
Biological Process lens development in camera-type eyeIEA:Ensembl
Biological Process Leydig cell proliferationIEA:Ensembl
Biological Process negative regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process negative regulation of skeletal muscle satellite cell proliferationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatid developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Branchiootorenal syndrome 2 (BOR2):
A syndrome characterized by branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, structural defects of the outer, middle or inner ear, and renal malformations.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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