SI

This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.

sucrase-isomaltase (alpha-glucosidase)

Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.

Biological Process polysaccharide digestionTAS:Reactome
Biological Process sucrose catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Apical cell membrane

Cytoplasmic: 2-12
Helical: 13-32
Lumenal: 33-1827