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Mouse Anti-SI Antibody (HBB2/219/20) (CBMAB-1563CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
HBB2/219/20
Antibody Isotype
IgG2b
Application
ELISA, IF, IHC, IP

Basic Information

Immunogen
Purified intestinal brush border membrane from normal adult human jejunal mucosa
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sucrase-isomaltase (alpha-glucosidase)
Introduction
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. The protein plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides. Diseases associated with SI include Sucrase-Isomaltase Deficiency, Congenital and Congenital Sucrase-Isomaltase Deficiency With Starch Intolerance. Among its related pathways are Metabolism and Galactose metabolism.
Entrez Gene ID
6476
UniProt ID
P14410
Alternative Names
sucrase-isomaltase
Function
Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.
Biological Process
Biological Process polysaccharide digestionTAS:Reactome
Biological Process sucrose catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Apical cell membrane
Topology
Cytoplasmic: 2-12
Helical: 13-32
Lumenal: 33-1827
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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