SHC4

SHC4 (SHC Adaptor Protein 4) is a protein coding gene. Diseases associated with SHC4 include Male Reproductive Organ Cancer. Among its related pathways are Endometrial cancer and MicroRNAs in cancer. Gene Ontology annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.

SHC4

Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.

Biological Process apoptotic processIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl
Biological Process stem cell differentiationIEA:Ensembl
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Postsynaptic cell membrane
Colocalized with MUSK at the neuromuscular junction.

Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.