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Mouse Anti-SHC4 Recombinant Antibody (CBXS-0354) (CBMAB-S3325-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0354
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
SHC4 (AAH33907, 1 a.a.-630 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites fluid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SHC4
Introduction
RaLP encodes a 69-kDa protein characterized by the CH2-PTB-CH1-SH2 modularity, typical of the Shc protein family, and expressed, among adult tissues, only in melanomas. This protein activates both Ras-dependent and Ras-independent migratory pathways in melanomas. It also contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Entrez Gene ID
399694
UniProt ID
Q6S5L8
Alternative Names
SHC Adaptor Protein 4; Rai-Like Protein; Src Homology 2 Domain-Containing-Transforming Protein C4; SHC (Src Homology 2 Domain Containing) Family, Member 4; SHC-Transforming Protein D; SH2 Domain Protein C4;
Function
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Biological Process
Biological Process apoptotic processIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl
Biological Process stem cell differentiationIEA:Ensembl
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Postsynaptic cell membrane
Colocalized with MUSK at the neuromuscular junction.
PTM
Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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