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Recombinant Mouse Anti-SHC4 Recombinant Antibody (AI22-20) (CBMAB-XB1033-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
AI22-20
Application
IHC, IF, WB

Basic Information

Specificity
Human, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SHC4
Introduction
SHC4 (SHC Adaptor Protein 4) is a protein coding gene. Diseases associated with SHC4 include Male Reproductive Organ Cancer. Among its related pathways are Endometrial cancer and MicroRNAs in cancer. Gene Ontology annotations related to this gene include protein kinase binding and receptor tyrosine kinase binding. An important paralog of this gene is SHC1.
Entrez Gene ID
Human399694
Mouse271849
UniProt ID
HumanQ6S5L8
MouseQ6S5L9
Alternative Names
SHC Adaptor Protein 4; Rai-Like Protein; Src Homology 2 Domain-Containing-Transforming Protein C4; SHC (Src Homology 2 Domain Containing) Family, Member 4; SHC-Transforming Protein D; SH2 Domain Protein C4;
Function
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Biological Process
Biological Process apoptotic processIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process positive regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of gene expressionIEA:Ensembl
Biological Process stem cell differentiationIEA:Ensembl
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Postsynaptic cell membrane
Colocalized with MUSK at the neuromuscular junction.
PTM
Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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