SEZ6L2

This gene encodes a seizure-related protein that is localized on the cell surface. The gene is located in a region of chromosome 16p11.2 that is thought to contain candidate genes for autism spectrum disorders (ASD), though there is no evidence directly implicating this gene in ASD. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer. Alternative splicing of this gene results in multiple transcript variants.

seizure related 6 homolog like 2

May contribute to specialized endoplasmic reticulum functions in neurons.

Biological Process regulation of protein kinase C signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse maturationManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane
Endoplasmic reticulum membrane
Detected on cell surface of lung-cancer.

Extracellular: 28-844
Helical: 845-865
Cytoplasmic: 866-910

O-glycosylated with core 1 or possibly core 8 glycans.