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SERPINA6

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Full Name
Serpin Family A Member 6
Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Biological Process
Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
PTM
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.

Anti-SERPINA6 antibodies

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Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP337
Application*: ICC, IHC, IP, WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP336
Application*: ICC, IHC, IP, WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F11
Application*: WB, E
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D9
Application*: WB, E
Target: SERPINA6
Host: Mouse
Specificity: Human
Clone: CBXS-3033
Application*: E, WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXS-1984
Application*: WB, IH
Target: SERPINA6
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1826
Application*: WB
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4763
Application*: E, WB
Target: SERPINA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-4713
Application*: E
Target: SERPINA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3714
Application*: E
Target: SERPINA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11BA23
Application*: E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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