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Rat Anti-SERPINA6 Recombinant Antibody (CBXS-1826) (CBMAB-S4632-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-1826
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
NS0-derived recombinant mouse Serpin A6, Val23-Ala397, Accession # Q06770
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serpin Family A Member 6
Introduction
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.
Entrez Gene ID
12401
UniProt ID
Q06770
Alternative Names
Cbg
Function
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Biological Process
Biological Process glucocorticoid metabolic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Involvement in disease
Corticosteroid-binding globulin deficiency (CBG deficiency):
Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
PTM
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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