SEMA7A

The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

Biological Process axon extensionIEA:Ensembl
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process olfactory lobe developmentIEA:Ensembl
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process positive regulation of axon extensionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of macrophage cytokine productionISS:UniProtKB
Biological Process positive regulation of protein phosphorylationIEA:Ensembl
Biological Process protein phosphorylationIEA:Ensembl
Biological Process regulation of inflammatory responseISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane
Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.