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Rat Anti-SEMA7A Recombinant Antibody (MM0537-99D22) (CBMAB-0816CQ)


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Summary

Host Animal
Rat
Specificity
Human
Clone
MM0537-99D22
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Amino acids 46-645 of Human Semaphorin 7a
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Introduction
This gene encodes a member of the semaphorin family of proteins. Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Entrez Gene ID
8482
UniProt ID
O75326
Alternative Names
JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
Function
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Biological Process
Biological Process axon extensionIEA:Ensembl
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process olfactory lobe developmentIEA:Ensembl
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process positive regulation of axon extensionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of macrophage cytokine productionISS:UniProtKB
Biological Process positive regulation of protein phosphorylationIEA:Ensembl
Biological Process protein phosphorylationIEA:Ensembl
Biological Process regulation of inflammatory responseISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
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For research use only. Not intended for any clinical use.

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