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Mouse Anti-SEMA7A Recombinant Antibody (MEM-150) (CBMAB-0817CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
MEM-150
Antibody Isotype
IgM
Application
IF, FC, IP, WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Introduction
This gene encodes a member of the semaphorin family of proteins. Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Entrez Gene ID
Human8482
Mouse20361
UniProt ID
HumanO75326
MouseQ9QUR8
Alternative Names
JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1
Function
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Biological Process
Biological Process axon extensionIEA:Ensembl
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process olfactory lobe developmentIEA:Ensembl
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process positive regulation of axon extensionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of macrophage cytokine productionISS:UniProtKB
Biological Process positive regulation of protein phosphorylationIEA:Ensembl
Biological Process protein phosphorylationIEA:Ensembl
Biological Process regulation of inflammatory responseISS:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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