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SDC1

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]

Full Name

Syndecan 1

Function

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).

Biological Process

Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory responseIEA:Ensembl
Biological Process myoblast developmentISS:UniProtKB
Biological Process odontogenesisIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process response to calcium ionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to glucocorticoidIEA:Ensembl
Biological Process response to hydrogen peroxideIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process Sertoli cell developmentIEA:Ensembl
Biological Process striated muscle cell developmentManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl

Cellular Location

Membrane
Secreted
Secreted, extracellular exosome
Shedding of the ectodomain produces a soluble form.

Topology

Extracellular: 23-254
Helical: 255-275
Cytoplasmic: 276-310

PTM

Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.

Anti-SDC1 antibodies

Mouse Anti-SDC1 Monoclonal Antibody (1A3H4) (CBMAB-1601-YC)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 1A3H4

Application*: P, IC, IF, F, WB

Mouse Anti-SDC1 Monoclonal Antibody (B-A38) (CBMAB-1600-YC)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: B-A38

Application*: F, FN, IC, IF, C, P, WB

Mouse Anti-SDC1 Monoclonal Antibody (BA38) (CBMAB-1599-YC)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: BA38

Application*: IC, IF, C, F, P, FN, WB

Rat Anti-SDC1 Recombinant Antibody (CBXS-2633) (CBMAB-S5387-CQ)

SDS

Target: SDC1

Host: Rat

Specificity: Mouse

Clone: CBXS-2633

Application*: F, IC, IP, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-2526) (CBMAB-S5282-CQ)

SDS

Target: SDC1

Host: Mouse

Specificity: Human, Mouse

Clone: CBXS-2526

Application*: E, IC, IH, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-2501) (CBMAB-S5258-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-2501

Application*: F, IH

Mouse Anti-SDC1 Recombinant Antibody (CBXS-1985) (CBMAB-S4754-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-1985

Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBXS-1770) (CBMAB-S4587-CQ)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXS-1770

Application*: WB, IP

Rabbit Anti-SDC1 Recombinant Antibody (CBXS-1545) (CBMAB-S4394-CQ)

SDS

Target: SDC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1545

Application*: WB, P, F

Mouse Anti-SDC1 Recombinant Antibody (CBXS-0161) (CBMAB-S3148-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0161

Application*: P, C, F

Rat Anti-SDC1 (AA 18-251) Recombinant Antibody (CBXS-0160) (CBMAB-S3147-CQ)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0160

Application*: E, F, IH

Mouse Anti-SDC1 Recombinant Antibody (CBXS-4247) (CBMAB-S1499-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-4247

Application*: E, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-3886) (CBMAB-S1155-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3886

Application*: E, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-5705) (CBMAB-S0573-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-5705

Application*: E, WB, IH

Rabbit Anti-SDC1 Monoclonal Antibody (SP152) (CBMAB-1602-YC)

SDS

Target: SDC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP152

Application*: P

Mouse Anti-SDC1 Recombinant Antibody (CBXC-1819) (CBMAB-C4572-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1819

Application*: E

Mouse Anti-SDC1 Recombinant Antibody (CBWJC-4412) (CBMAB-C5794WJ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4412

Application*: E

Mouse Anti-SDC1 Recombinant Antibody (CBWJC-4411) (CBMAB-C5793WJ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4411

Application*: F

Mouse Anti-SDC1 Recombinant Antibody (SB55a) (CBMAB-S6548-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: SB55a

Application*: F, IH, P, C

Mouse Anti-SDC1 Recombinant Antibody (MI15) (CBMAB-S6429-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: MI15

Application*: F, IH, IF, P

Mouse Anti-SDC1 Recombinant Antibody (CBXS-1154) (CBMAB-S4036-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1154

Application*: E, WB

Rabbit Anti-SDC1 Recombinant Antibody (CBXS-1056) (CBMAB-S3947-CQ)

SDS

Target: SDC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXS-1056

Application*: E

Rabbit Anti-SDC1 Recombinant Antibody (CBXS-5404) (CBMAB-S2616-CQ)

SDS

Target: SDC1

Host: Rabbit

Specificity: Human

Clone: CBXS-5404

Application*: WB, IP, F

Mouse Anti-SDC1 Recombinant Antibody (531CT15.4.1) (CBMAB-C4237-CN)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 531CT15.4.1

Application*: E, WB

Mouse Anti-SDC1 Recombinant Antibody (CBXS-5659) (CBMAB-S0260-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5659

Application*: E, F, IC, IF, WB

Mouse Anti-SDC1 Recombinant Antibody (V92-P3D9/E7) (CBMAB-S0192-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V92-P3D9/E7

Application*: WB, E, IH

Mouse Anti-SDC1 Recombinant Antibody (DL-101) (CBMAB-S0185-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: DL-101

Application*: F, C, P

Rat Anti-SDC1 Recombinant Antibody (CBXS-1796) (CBMAB-S0115-CQ)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1796

Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBXS-1756) (CBMAB-S0108-CQ)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXS-1756

Application*: F

Human Anti-SDC1 Recombinant Antibody (CBXC-0706) (CBMAB-C1819-CQ)

SDS

Target: SDC1

Host: Human

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXC-0706

Application*: F

Mouse Anti-SDC1 Recombinant Antibody (CBXC-2886) (CBMAB-C1675-CQ)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2886

Application*: F

Mouse Anti-SDC1 Recombinant Antibody (CBFYC-3093) (CBMAB-C3170-FY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3093

Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBFYC-0498) (CBMAB-C0549-FY)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBFYC-0498

Application*: F, IH, IF

Rat Anti-SDC1 Recombinant Antibody (281-2) (CBMAB-C0785-LY)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 281-2

Application*: F, C

Mouse Anti-SDC1 Recombinant Antibody (480CT5.4.3) (CBMAB-C6520-LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 480CT5.4.3

Application*: WB, E

Mouse Anti-SDC1 Recombinant Antibody (531CT15.4.1;531CT15.1.4) (CBMAB-C7158-LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 531CT15.4.1;531CT15.1.4

Application*: WB

Mouse Anti-SDC1 Recombinant Antibody (5G71) (CBMAB-C7688-LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5G71

Application*: E, IH, IP, WB

Mouse Anti-SDC1 Recombinant Antibody (6A372) (CBMAB-C8019-LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6A372

Application*: E, F, IH

Rat Anti-SDC1 Recombinant Antibody (7H32) (CBMAB-C8845-LY)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: 7H32

Application*: E, F, IH

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C0232) (CBMAB-C0674-YY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C0232

Application*: F

Rat Anti-SDC1 Recombinant Antibody (CBYY-C0662) (CBMAB-C1955-YY)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C0662

Application*: E, F, IH

Rat Anti-SDC1 Recombinant Antibody (CBYY-C1164) (CBMAB-C2601-YY)

SDS

Target: SDC1

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1164

Application*: F

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1165) (CBMAB-C2602-YY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1165

Application*: WB, E

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1166) (CBMAB-C2603-YY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1166

Application*: WB

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1167) (CBMAB-C2604-YY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C1167

Application*: E, IH, IP, WB

Mouse Anti-SDC1 Recombinant Antibody (CBYY-C1168) (CBMAB-C2605-YY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1168

Application*: E, F, IH

Recombinant Mouse Anti-SDC1 Recombinant Antibody (V92-P3D9) (CBMAB-XB1029-YC)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V92-P3D9

Application*: E, IH, WB

Mouse Anti-SDC1 Recombinant Antibody (1B4F4) (CBMAB-R4271-CN)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: 1B4F4

Application*: E

Mouse Anti-SDC1 Recombinant Antibody (3A2C8) (CBMAB-R4279-CN)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3A2C8

Application*: E

Mouse Anti-SDC1 Recombinant Antibody (1D4) (CBMAB-C12373-LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D4

Application*: F

Rabbit Anti-SDC1 Recombinant Antibody (D4Y7H) (CBMAB-CP2373-LY)

SDS

Target: SDC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D4Y7H

Application*: WB, IP, F

Mouse Anti-SDC1 Recombinant Antibody (IHC138) (CBMAB-MA218-YC)

SDS

Target: SDC1

Host: Mouse

Specificity: Human

Clone: IHC138

Application*: IH

Mouse Anti-SDC1 Recombinant Antibody (CB318A) (CBMAB-CA318LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CB318A

Application*: ELISA

Mouse Anti-SDC1 Recombinant Antibody (CB320A) (CBMAB-CA320LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CB320A

Application*: ELISA

Mouse Anti-SDC1 Recombinant Antibody (CF383) (CBMAB-FT397LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF383

Application*: ELISA, WB

Mouse Anti-SDC1 Recombinant Antibody (CF384) (CBMAB-FT399LY)

SDS

Target: SDC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CF384

Application*: ELISA, WB, IHC

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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