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Mouse Anti-SDC1 Monoclonal Antibody (B-A38) (CBMAB-1600-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
B-A38
Antibody Isotype
IgG1
Application
FC, FuncS, ICC, IF, IHC-Fr, IHC-P, WB

Basic Information

Immunogen
U266 cell line
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Syndecan 1
Introduction
SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types.
Entrez Gene ID
Human6382
Mouse20969
Rat25216
UniProt ID
HumanP18827
MouseP18828
RatP26260
Alternative Names
SDC; CD138; SYND1; syndecan
Function
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Biological Process
Biological Process canonical Wnt signaling pathwayIEA:Ensembl
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process inflammatory responseIEA:Ensembl
Biological Process myoblast developmentISS:UniProtKB
Biological Process odontogenesisIEA:Ensembl
Biological Process positive regulation of exosomal secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of extracellular exosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process response to calcium ionIEA:Ensembl
Biological Process response to cAMPIEA:Ensembl
Biological Process response to glucocorticoidIEA:Ensembl
Biological Process response to hydrogen peroxideIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process Sertoli cell developmentIEA:Ensembl
Biological Process striated muscle cell developmentManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process wound healingIEA:Ensembl
Cellular Location
Membrane
Secreted
Secreted, extracellular exosome
Shedding of the ectodomain produces a soluble form.
Topology
Extracellular: 23-254
Helical: 255-275
Cytoplasmic: 276-310
PTM
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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