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S100B

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
Full Name
S100 Calcium Binding Protein B
Function
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Biological Process
Biological Process axonogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process learning or memoryISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus

Anti-S100B antibodies

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Target: S100B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2691
Application*: E, IH, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Cat, Goat, Human, Sheep, Pig, Rabbit, Rat
Clone: SH-B4
Application*: WB, IF, IC, P, E
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9A11B9
Application*: WB, IH
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: S1-61
Application*: IH
Target: S100B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: S100B/1012
Application*: WB, F, IF, P
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2435
Application*: E, IH, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-2358
Application*: IH, IP, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Cattle, Cat, Rabbit
Clone: SH-B1
Application*: WB, F, IF, P, MC
Target: S100B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Cattle
Clone: SPM354
Application*: WB, F, IF, P, MC
Target: S100B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3742
Application*: WB, F, IH, IF, P
Target: S100B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3744
Application*: WB, F, IH, IF, P
Target: S100B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle
Clone: S100B/1706R
Application*: WB, F, IF, P, MC
Target: S100B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBXS-5770
Application*: WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5805
Application*: WB
Target: S100B
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Mouse
Clone: CBXS-4300
Application*: WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-4301
Application*: WB, IH, P
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBXS-4333
Application*: IH, WB
Target: S100B
Host: Mouse
Specificity: Human
Clone: CBXS-2665
Application*: E, WB
Target: S100B
Host: Mouse
Specificity: Rat
Clone: CBXS-2504
Application*: E, IC, IH, WB
Target: S100B
Host: Mouse
Specificity: Human
Clone: CBXS-0093
Application*: WB, IC, P, C, E
Target: S100B
Host: Mouse
Specificity: Rat
Clone: CBXS-0094
Application*: WB, IC, P, C, E
Target: S100B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1834
Application*: WB
Target: S100B
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2264
Application*: WB, IP, IF, E
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2309
Application*: E, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 5G3-C11
Application*: WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A19
Application*: WB, E
Target: S100B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A10
Application*: WB, E
Target: S100B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2A11
Application*: WB, E
Target: S100B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM304
Application*: IHC, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5231
Application*: E, WB
Target: S100B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-5328
Application*: WB
Target: S100B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Goat, Human, Zebrafish, Monkey
Clone: CBXS-5466
Application*: IF, WB, IP, P
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A1B1
Application*: E
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB313A
Application*: ELISA
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G1
Application*: E, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Cattle, Mouse, Rat, Human
Clone: 4C4.9
Application*: F, IC, IF, P, WB
Target: S100B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 16H24L21
Application*: WB, P
Target: S100 Alpha/Beta
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B10
Application*: E, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: SA-12
Application*: P, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: PS1B1-1
Application*: F, IF, P
Target: S100B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-6173
Application*: E, WB
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G4B9
Application*: E
Target: S100B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: F5H7
Application*: E
Target: S100B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Human
Clone: CBXS-3139
Application*: E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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