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Mouse Anti-S100B Recombinant Antibody (SH-B4) (CBMAB-0794CQ)


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Summary

Host Animal
Mouse
Specificity
Cattle, Dog, Cat, Goat, Human, Sheep, Pig, Rabbit, Rat
Clone
SH-B4
Antibody Isotype
IgG1
Application
WB, IF, ICC, IHC-P, ELISA

Basic Information

Immunogen
Purified, full length, native bovine S100b protein
Specificity
Cattle, Dog, Cat, Goat, Human, Sheep, Pig, Rabbit, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
S100 Calcium Binding Protein B
Introduction
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Entrez Gene ID
Human6285
Cattle525716
Rat116547
Dog491615
Cat101099488
Goat102169524
Pig100623510
Rabbit100009495
UniProt ID
HumanP04271
DogA0A8C0RT29
CattleP02638
RatP04631
CatA0A2I2UW07
GoatM4N9R3
SheepW5PVB6
RabbitQ6YNR6
Alternative Names
S100B; S100 calcium binding protein B; NEF; S100; S100-B; S100beta; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural)
Function
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Biological Process
Biological Process axonogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process learning or memoryISS:UniProtKB
Biological Process memoryIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of neuronal synaptic plasticityIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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