RPS6KA2

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

ribosomal protein S6 kinase, 90kDa, polypeptide 2

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Biological Process brain renin-angiotensin systemIEA:Ensembl
Biological Process cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process cellular response to carbohydrate stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionTAS:Reactome
Biological Process heart contractionIEA:Ensembl
Biological Process heart developmentIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of meiotic nuclear divisionIEA:Ensembl
Biological Process oocyte maturationIEA:Ensembl
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of protein processingIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:ProtInc

Nucleus
Cytoplasm

Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
N-terminal myristoylation results in an activated kinase in the absence of added growth factors.