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Mouse Anti-RPS6KA2 Recombinant Antibody (3A3) (CBMAB-R3538-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3A3
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Introduction
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Entrez Gene ID
6196
UniProt ID
Q15349
Alternative Names
Ribosomal Protein S6 Kinase A2; MAP Kinase-Activated Protein Kinase 1c; MAPK-Activated Protein Kinase 1c; Ribosomal S6 Kinase 3; EC 2.7.11.1; MAPKAPK1C; Pp90RSK3; P90RSK2; RSK3; Mitogen-Activated Protein Kinase-Activated Protein Kinase 1C; Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2; Ribosomal Protein S6 Kinase, 90kD, Polypeptide 2; 90 KDa Ribosomal Protein S6 Kinase 2; Ribosomal Protein S6 Kinase Alpha-2;
Function
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Biological Process
Biological Process brain renin-angiotensin systemIEA:Ensembl
Biological Process cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process cellular response to carbohydrate stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionTAS:Reactome
Biological Process heart contractionIEA:Ensembl
Biological Process heart developmentIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of meiotic nuclear divisionIEA:Ensembl
Biological Process oocyte maturationIEA:Ensembl
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of protein processingIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
PTM
Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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