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Mouse Anti-RPS6KA2 Recombinant Antibody (3C1) (CBMAB-R3539-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
3C1
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human protein purified from E.coli (His/ABD-RSK3 aa. 415-733)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
HEPES, 0.01% BSA, 0.15M NaCl, 50% Glycerol
Preservative
0.03% Sodium azide
Concentration
2 mg/mL

Target

Full Name
ribosomal protein S6 kinase, 90kDa, polypeptide 2
Introduction
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Entrez Gene ID
Human6196
Mouse20112
Rat117269
UniProt ID
HumanQ15349
MouseQ9WUT3
RatF1M7N7
Alternative Names
RSK; HU-2; RSK3; p90RSK2; p90-RSK3; pp90RSK3; MAPKAPK1C; S6K-alpha; S6K-alpha2
Function
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Biological Process
Biological Process brain renin-angiotensin systemIEA:Ensembl
Biological Process cardiac muscle cell apoptotic processIEA:Ensembl
Biological Process cellular response to carbohydrate stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionTAS:Reactome
Biological Process heart contractionIEA:Ensembl
Biological Process heart developmentIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of meiotic nuclear divisionIEA:Ensembl
Biological Process oocyte maturationIEA:Ensembl
Biological Process peptidyl-serine phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process regulation of protein processingIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
PTM
Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
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For research use only. Not intended for any clinical use.

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