RHOJ

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM

ras homolog gene family, member J

Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707).
Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707).
Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707).

Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process Cdc42 protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cell shapeIEA:Ensembl
Biological Process regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process retina vasculature morphogenesis in camera-type eyeIEA:Ensembl

Cell membrane
Localization to the plasma membrane is regulated by GLUL.

Palmitoylated; regulates localization to the plasma membrane and may be mediated by GLUL.