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Mouse Anti-RHOJ Recombinant Antibody (CBYJT-1631) (CBMAB-T0677-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1631
Antibody Isotype
IgG2a
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ras homolog gene family, member J
Introduction
RHOJ is one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). RHOJ is activated by vascular endothelial growth factor and may regulate angiogenesis.
Entrez Gene ID
57381
UniProt ID
Q9H4E5
Alternative Names
Ras Homolog Family Member J; Ras Homolog Gene Family, Member J; Ras-Like Protein Family Member 7B; Tc10-Like GTP-Binding Protein; RAS-Like, Family 7, Member B; RASL7B; ARHJ
Function
Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707).
Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707).
Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707).
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process Cdc42 protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migration involved in sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of cell shapeIEA:Ensembl
Biological Process regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process retina vasculature morphogenesis in camera-type eyeIEA:Ensembl
Cellular Location
Cell membrane
Localization to the plasma membrane is regulated by GLUL.
PTM
Palmitoylated; regulates localization to the plasma membrane and may be mediated by GLUL.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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